AGT and hypertensive disorder: In those studies, additional interventions beyond OVX were implemented to generate adverse cardiac remodeling and fibrosis, including transverse aortic constriction, a high-fat diet, pharmacologic interventions to induce hypertension, including the administration of angiotensin II, deoxycorticosterone acetate, and salt, as well as the genetic manipulations of estrogen receptors type alpha and beta [10,11,12,13].