Furthermore, inhibition of Raf, MEK, and ERK countered the decrease in miR-2277-3p synthesis induced by visfatin, suggesting that visfatin modulates VEGF-D-dependent lymphangiogenesis in chondrosarcoma by reducing miR-2277-3p levels through the Raf, MEK, and ERK pathway. This evidence concerns the gene NAMPT and chondrosarcoma.