Both ASPM and BUB1 interact with UBE2C, KIF23, KIF2C, KIF11, NUF2, CDK1, BUB1B and NUSAP1, each of which has previously been associated with the initiation and/or progression of PAAD [25,26,27,28,29,30,31,32]. Here, BUB1B is linked to pancreatic adenocarcinoma.