Skeletal muscle inflammation in the context of CKD has been studied in nephrectomized rodents (Figure 1), where elevations in the expression levels of various cytokines, including interleukin (IL) 1β, IL4, IL6, tumor necrosis factor (TNF) α, and interferon (IFN) γ, and of macrophage markers such as F4/80, have been detected [72,73,81,83,84,85,162,163]. The gene discussed is IL6; the disease is chronic kidney disease.