CREB1 and Alzheimer disease: In conclusion, our study indicates that curcumin decreases the activity of GSK3β in Aβ1–42 mice by targeting PI3K/Akt, enhancing Wnt/β-catenin; moreover, it increases the activity of CREB, enhancing the BDNF content, which consequently improves adult neurogenesis and the spatial cognitive function of AD mice (Graphical Abstract).