In conclusion, our study indicates that curcumin decreases the activity of GSK3β in Aβ1–42 mice by targeting PI3K/Akt, enhancing Wnt/β-catenin; moreover, it increases the activity of CREB, enhancing the BDNF content, which consequently improves adult neurogenesis and the spatial cognitive function of AD mice (Graphical Abstract). This evidence concerns the gene AKT1 and Alzheimer disease.