Given that diabetic patients showed a higher probability of experiencing an unfavorable evolution (Figure 1A) without demonstrating significantly elevated levels of parameters associated with poor outcomes in the overall study population (NLR, D-Dimers, NETs, S100A8/A9), we formulated the hypothesis that these paraclinical parameters may have different clinical implications for patients with and without diabetes. Here, IGKV1D-22 is linked to diabetes mellitus.