Therefore, using RNA extracted from PLAP+ EVs isolated with EV-CATCHER from the plasma of women diagnosed with placenta previa (n = 16; controls) and women diagnosed with placenta percreta (cases; n = 16), with a mean gestational age of 35 ± 4 weeks and 33 ± 4 weeks, respectively (Figure 2), we prepared small-RNA cDNA libraries for next generation sequencing (NGS) analyses. Here, ALPP is linked to placenta praevia.