In this pilot study, we isolated, analyzed, and profiled the miRNA cargos of placental (PLAP+) EVs isolated from the maternal plasma of women with placenta previa (control) and placenta percreta (case) pregnancies using an antibody targeting the placental alkaline phosphatase (PLAP) membrane protein, which is uniquely produced by placental cells [61]. Here, ALPP is linked to placenta accreta.