The initiation and progression of melanoma are mediated via genetic and epigenetic alterations to the key molecules in multiple signaling pathways, such as the RAS/RAF/MAPK, JNK, PI3K/Akt and Jak/STAT pathways; they are also influenced by the dysregulation of the MITF (Microphthalmia-Associated Transcription Factor) protein [4,5,6,7]. This evidence concerns the gene MITF and melanoma.