However, previous studies have demonstrated that, for example, the CORVET and HOPS complexes seem to have a general function in different functions requiring intracellular trafficking (e.g., early vesicle formation, phagocytosis, endo-lysosomal trafficking, autophagy), and the observation that such processes are altered by NPM1 interacting agents, especially in NPM1-Ins AML cells, strongly suggests that our present observations are functionally relevant [114]. The gene discussed is NPM1; the disease is acute myeloid leukemia.