The 33 proteins showing significantly increased levels in NPM1-Ins AML cells and included in the PPI networks (Figure 1b) are important for several key regulatory mechanisms of the cellular functions described above, i.e., endocytosis, communication between intracellular compartments, vesicular transport, or exosome release, as discussed below [26,27,28,29,30,31]. Here, NPM1 is linked to acute myeloid leukemia.