The model of RIPC and liver IR reported here provides some interesting findings with relation to the association between liver IR injury, AKI, and NGAL but also raises further questions regarding the nature of the relationship between the three and specifically the role of the ischaemic versus non-ischaemic liver lobe in the local and systemic response to IR injury and NGAL release. The gene discussed is LCN2; the disease is digestive system neoplasm.