HSD11B1 and diabetes mellitus: We observed significantly lower expression levels of each gene in visceral tissues of diabetic patients than in obese subjects without diabetes: p < 0.001 for GR (Figure 3a), p < 0.0001 for H6PDH (Figure 3b), p < 0.01 for HSD11B1 (Figure 3c), and p < 0.0001 for HSD11B2 (Figure 3d).