NR3C1 and obesity due to melanocortin 4 receptor deficiency: Since in the presented study, there were no differences in the concentration of this glucocorticoid in the tissues obtained from obese and normal-weight subjects, one can conclude that the decreased expression of GR in the course of obesity can act as a protective mechanism preventing the dysfunctional adipose tissue from the additive, detrimental impact of glucocorticoids, aggravating, for example, insulin resistance or adipogenesis [24,25].