ALOX12B-related phenotypes in our patients were heterogeneous and characterized by congenital mild/moderate erythroderma on the face and trunk, hyperlinearity of the hands, thin white or brownish scales on trunk and legs (Figure 1A–C); in two cases (ID.01 and ID.02), the phenotype evolved as SICI, one of these with fully normal skin. Here, ALOX12B is linked to exfoliative dermatitis.