It was found in trans with a known pathogenic large deletion removing exons 3–15 of ALOX12B (Figure 2A,B), in a child (case ID.04) with congenital dyskeratosis, pigmented areas of cutaneous xerosis located in the axillary region (Figure 1C), on the sides and the legs bilaterally, and very mild face erythroderma. The gene discussed is ALOX12B; the disease is Dry skin.