When directly comparing the transcriptomes of Mild- and AVD-MASH neutrophils (advanced × mild DEGs), we found that neutrophils from Mild-MASH cases expressed high levels of the pro-fibrotic factor TGFB1, the microfibrillar collagen COL6A3 and the pro-fibrotic metalloproteinases MMP25 and ADAMTSL4. The gene discussed is MMP25; the disease is metabolic dysfunction-associated steatohepatitis.