TGFB1 and metabolic dysfunction-associated steatohepatitis: When directly comparing the transcriptomes of Mild- and AVD-MASH neutrophils (advanced × mild DEGs), we found that neutrophils from Mild-MASH cases expressed high levels of the pro-fibrotic factor TGFB1, the microfibrillar collagen COL6A3 and the pro-fibrotic metalloproteinases MMP25 and ADAMTSL4.