Although neutrophils from ADV-MASH did not show the significant upregulation of antimicrobial peptide genes, they demonstrated the upregulation of genes encoding granzymes and perforin, suggesting that these cells may play a role in polymorphonuclear cell-mediated antibody-dependent cellular cytotoxicity in severe MASH. The gene discussed is PRF1; the disease is metabolic dysfunction-associated steatohepatitis.