In this large study (Wellcome Trust Case Control Consortium, involving 1926 patients with CAD and 2938 control subjects, replicated in the German Myocardial Infarction Family Study, involving 875 patients with myocardial infarction and 1644 control subjects), Samani and coworkers reported that the C allele of the SMAD3 gene (located at the locus 15q22.33 (rs17228212)) influences the risk of developing coronary artery disease [26]. This evidence concerns the gene SMAD3 and myocardial infarction.