In DKD, increased renal expression and elevated levels of NGAL in urine or blood have been associated with albuminuria, decreased eGFR, and histological markers of kidney damage, such as tubulointerstitial fibrosis and glomerulosclerosis, suggesting that NGAL may serve as a marker of disease severity and progression in DKD [97,98,99]. This evidence concerns the gene LCN2 and glomerulosclerosis.