For IDH2R140Q-specific T-cell clones, no reactivity was observed against K562-R140Q transduced with HLA-B*07:02 or patient-derived AML cells (AML 9448) with IDH2R140Q, while all T-cell clones reacted against K562-R140Q cells transduced with HLA-B*07:02 and the full-length IDH2R140Q gene (Figure 5C). Here, HLA-B is linked to acute myeloid leukemia.