PLAU and ovarian cancer: HGF and GRO-1 promote the cellular senescence of mesothelial cells and increase the production of hyaluronic acid, u-PA (urokinase plasminogen activator), IL-8 (interleukin-8), and MCP-1 (monocyte chemotactic protein-1), which stimulate cell adhesion, proliferation, and migration in ovarian cancer [25].