However, none of the above were amongst the hub genes identified in a study that integrated co-methylated and co-expressed genes in non-seminomas versus seminomas, with the hypomethylated and upregulated group including a series of 39 genes, while the hypermethylated and down-regulated group included only 2 genes, namely ZNF438 and FAM41C [80]. Here, ZNF438 is linked to seminoma.