In contrast, IL-6, IL-1β, and TNF-α were synergistically suppressed in the cecal tissue of mice that had undergone chemotherapy and developed gut-derived P. aeruginosa sepsis but were treated with a combination of active 1,25D3 and butyrate whereas IL-17A, IL-22, CRAMP, ATG16L1 and AhR were synergistically enhanced. The gene discussed is IL22; the disease is Sepsis.