FOXP3 and amyotrophic lateral sclerosis: The first main finding of our work is the demonstration that the decreased number of Tregs in the peripheral blood of ALS patients and decreased FoxP3 mRNA is associated with a reduced portion of the FL FoxP3 splice variant (Figure 1) and an increased proportion of the truncated ∆2, ∆7, and ∆2∆7 variants in comparison with healthy donors.