Similarly, the median level of circulating RANKL in T2D individuals was 9.25 (17.3) pg/mL, while that in non-diabetic individuals was 0.21 (9.94) pg/mL, and the level of GPNMB in circulation in people with T2D was 21.44 (7) ng/mL, while that in non-diabetic individuals was 18.65 (5) ng/mL. The gene discussed is GPNMB; the disease is type 2 diabetes mellitus.