Interestingly, there was also a significant upregulation in the PGC1α expression (~2.4 fold, ALS-IMS v/s NALS; Figure 5I) which exceeded the upregulation observed in the ALS group (~1.7 fold, ALS-IMS v/s ALS; Figure 5I). Here, PPARGC1A is linked to amyotrophic lateral sclerosis.