NFASC and amyotrophic lateral sclerosis: Our interpretation is that IMS-088 was able to alleviate the abnormal distribution of NF proteins in soma and axons triggered by ALS-CSF exposure, but there was some irreversible loss of NF proteins due to neuronal death after ALS-CSF infusion, especially before initiation of treatment with IMS-088 at two days after beginning of i.c.v. infusion of ALS-CSF (Figure 2A–H).