Inhibition of NF-κB, a transcription factor that regulates cellular expression of many pro-inflammatory factors, by the root extract of the medicinal herbal plant Withania somnifera, mitigated TDP-43 proteinopathy and improved motor performance of a transgenic mouse model of ALS/FTLD with TDP-43 pathology [23]. Here, NFKB1 is linked to amyotrophic lateral sclerosis.