As a result of this, it has been proven that patients who maintain in plasma high concentrations of small-sized EVs and who have in their outer membrane the asialo-glycoprotein receptor 2 (ASGR2) and cytochrome P450 Family 2 Subfamily E Member (CYP2E1) proteins typical of hepatocytes are related to NASH and the decrease of these proteins and the increase of larger-sized EVs is due to the resolution of the disease [13]. The gene discussed is ASGR2; the disease is metabolic dysfunction-associated steatohepatitis.