CASP3 and Hepatic failure: In diseases that lead to liver failure, attempts are being made to find a possible treatment by isolating exosomes from bone marrow mesenchymal stem cells to protect liver cells from apoptosis, since it has been proven that these exosomes induce the activation of autophagy, releasing autophagosomes and autolysosomes and generating an increase in LC3B II, the anti-apoptotic protein bcl-2, and a decrease in the pro-apoptotic protein caspase-3 (cleaved caspase-3) [82].