PPARA and steatosis: Similarly, HFD-induced steatosis was more pronounced, and evident liver necroinflammation and fibrosis were observed in the pparα−/−/cyp2a5−/− mice, but not in the cyp2a5−/− mice or the pparα−/− mice [14,15], suggesting that PPARα is still protective against the HFD-induced steatosis, steatohepatitis, and fibrosis in the cyp2a5−/− mice.