Regarding tissue IL-8 levels, there was a stepwise significant increase observed in CHR patients (44.8 [78.6], median [IQR] pg/mL) compared to CRSsNP patients (158.8 [194.5] pg/mL) that was further elevated in the CRSwNP group ((291.5 [382.5] pg/mL) p < 0.05 in post hoc test) (Figure 3). The gene discussed is CXCL8; the disease is chronic rhinosinusitis with nasal polyps.