Figure 4 depicts the elevated serum levels of (A) TNFα, (B) IL-6, and (C) IL-8 in NEC (p < 0.05 vs. Ctrl + mAb) and their reduction in rat pups that received ALT-100, the eNAMPT-neutralizing mAb (p < 0.01 vs. NEC). The gene discussed is TNF; the disease is necrotizing enterocolitis.