For example, Downes et al. described intense AR positivity in 100% of prostatic cancers and negative or only weak staining in urothelial carcinomas and found that AR IHC was superior to prostate specific markers such as PSA and PSAP in discriminating poorly differentiated urothelial carcinoma from high grade prostate carcinoma [29]. This evidence concerns the gene AR and urothelial carcinoma.