The proven association between Ang2 and nephropathy [6,7,9,11], as well as the link between ANGPTL8 and renal dysregulation [18,41,42], and the presence of a positive correlation between Ang2 and ANGPTL8 all point to a possible interplay between these proteins contributing to DN’s progression or severity. The gene discussed is ANGPTL8; the disease is liver dysplastic nodule.