CRP and cholangiocarcinoma: Therefore, as also shown in the present study, it is hardly surprising that a significant correlation of FDG uptake in the BM and spleen with serum inflammatory markers such as CRP, NLR, and PLR has been consistently reported, suggesting the role of FDG uptake of the BM and spleen as an imaging biomarker for estimating the degree of systemic inflammatory response in patients with malignant diseases, including cholangiocarcinoma [19,22,23,24,25].