Notably, pro-inflammatory cytokines such as IL-6 and TNF-α play important roles in the pathogenesis of many diseases [33], and TNF-α is capable of stimulating the in vitro proliferation of androgen-producing theca cells [22,34] showed administration of Zea to female rats for three months to increase plasma TNF-α and the expression of Secreted frizzled-related protein 4 (SFRP4), an adipokine involved in the apoptotic process during ovulation and energy metabolism; therefore, this is a deterministic factor in the progress of PCOS. This evidence concerns the gene SFRP4 and polycystic ovary syndrome.