SIL and FCD treatment significantly increased the mRNA expression levels of Occludin, ZO-1, and Claudin-1 (p < 0.05) and decreased the NLRP3 and TNF-α levels (p < 0.01), indicating the therapeutic potential of FCD similar to SIL. Here, NLRP3 is linked to squamous cell intraepithelial neoplasia.