While several medicinal plants present direct antioxidant activity with fewer adverse effects and could serve as alternative treatments for ulcer diseases [64], AOS can operate through a distinct mechanism, as shown here, involving the p62/SQSTM1/Keap1/Nrf2 axis to increase antioxidant enzymes and prevent damage to the gastric epithelium cell line. Here, KEAP1 is linked to ulcer disease.