Treatment of ovarian cancer cell line SHIN3 with ascorbate activated the protein ataxia–telangiectasia mutated (ATM) kinase, a key mediator of cellular response to DNA damage, through the activation of AMP-activated protein kinase (AMPK) and the inhibition of the mechanistic target of rapamycin (mTOR) pathways [16,94]. The gene discussed is MTOR; the disease is ovarian carcinoma.