The miRNA-sequencing of peripheral blood mononuclear cells (PBMC) from PD individuals showed a reduction in miR-30e-5p, which is positively and negatively correlated with nuclear receptor subfamily 4 group A member 2 (NURR1) and NLR family pyrin domain-containing 3 (NLRP3) expressions respectively, indicating the role in inflammatory pathology during the disease progression [189]. The gene discussed is NLRP3; the disease is Parkinson disease.