Longitudinal genome-wide methylation analysis in blood of PD individuals showed altered methylome patterns on the CpG sites of lamin tail domain-containing 1 (IFLTD1/LMNTD1), an intermediate filament protein, and delta-like non-canonical notch ligand 1 (DLK1), a transmembrane protein involved in differentiation of multiple cell types [169]. The gene discussed is DLK1; the disease is Parkinson disease.