A definitive diagnosis of AD is obtained at autopsy by histopathological presence of three main hallmarks of AD, i.e., extracellular senile plaques (SP, rich in amyloid β-peptide [Aβ])) and intracellular neurofibrillary tangles (NFTs, aggregate of hyperphosphorylated tau) and synapse loss [45]. Here, MAPT is linked to Alzheimer disease.