AMPK mainly mediates GFAT phosphorylation to reduce the O-GlcNAcylation of proteins such as troponin T and subsequently prevent cardiac hypertrophy predominantly; decreasing the O-GlcNAcylation by GFAT inhibitors of glutamine blocks cardiomyocyte hypertrophy, mimicking AMPK activation [41]. Here, GFPT1 is linked to cardiac hypertrophy.