Further research indicated that IFIT3 regulates the O-GlcNAcylation of VDAC2 by stabilizing the interaction of VDAC2 with OGT, and the increased O-GlcNAcylation of VDAC2 protects pancreatic ductal adenocarcinoma cells from chemotherapy-induced apoptosis by using the highly metastatic pancreatic ductal adenocarcinoma cell line L3.6pl and patient-derived primary cell TBO368 [109]. The gene discussed is VDAC2; the disease is pancreatic ductal adenocarcinoma.