Additionally, polymorphism in lipid metabolism and related transport-related genes, for instance, lipase c (LIPC), cholesteryl ester transfer protein (CETP), ATP-binding cassette subfamily A member 1 (ABCA1), and apolipoprotein E (APOE), also impart higher risk for AMD pathogenesis due to the accumulation of lipids and thickening of BrM [56]. Here, APOE is linked to age-related macular degeneration.