The phosphorylated NFE2L2 then translocates to the nucleus and forms a heterodimer complex with a musculoaponeurotic fibrosarcoma (Maf) protein in DNA to bind the antioxidant response element (ARE) in the promotor region of the cognate target gene for the expression of an array of phase II antioxidant enzymes and proteins including SOD, CAT, HO-1, NQO1, GST, and GCLC [88]. The gene discussed is CAT; the disease is fibrosarcoma.