Heterogeneous debris of several components including lipofuscin (LF), advanced glycation end products, apolipoprotein E, cholesterol, peroxidized lipids, carboxyethyl pyrrole adducts, vitronectin, amyloid P component, C-reactive protein, and complement factors (C3, C5, C9) have been reported in drusen and AMD lesions. The gene discussed is APOE; the disease is age-related macular degeneration.