Therefore, this study aims to (i) establish a possible relationship between cortisol levels and NOX2-mediated oxidative stress in students, (ii) evaluate a relationship between cortisol-mediated NOX2 activation and endothelial dysfunction, and (iii) demonstrate whether psychic stress, cortisol, oxidative stress, and endothelial dysfunction are associated with a reduction in academic performance. Here, CYBB is linked to endothelial dysfunction.