UGT1A1 and Hepatic fibrosis: In rats subjected to chronic CCl4-induced liver fibrosis, an alteration in the mRNA level of ugt isoforms was observed, with ugt1a1, 1a6, 2b1, and 2b2 mRNA levels being elevated, while ugt2b3, 2b6, and 2b12 mRNA levels were found to be reduced [52].