In agreement, in cells exposed to OM, the specific knockdown of LOX (Figure S3A) attenuated the increased levels of ROS and the exacerbated calcification of cell cultures, as well as the higher mRNA levels of the pro-oxidant enzyme NOX2 and the osteogenic marker osteopontin (encoded by SPP1) (Figure 7). This evidence concerns the gene CYBB and ocular melanoma.