HIF1A and Hepatic fibrosis: Recent research has unveiled that a nanomicellar carbon monoxide-releasing molecule, SMA/CORM2, can mitigate liver fibrosis induced by a high-fat methionine- and choline-deficient (HF-MCD) diet by inhibiting the hypoxia-inducible factor 1-alpha (HIF-1α)-mediated inflammatory cascade [65] (Figure 2).