Compared to the sham group, the SNL group had higher gene expression levels of Gadd45g (growth arrest and DNA-damage-inducible 45 gamma) and Fos (FBJ osteosarcoma oncogene), while it had lower gene expression levels of Igf1, Ccl2, Hdac2, Rtn4rl1, Nfkb2, Gpr84, Pik3cg, and Abcc8 (Figure 3A). This evidence concerns the gene HDAC2 and osteosarcoma.