CCL2 and osteosarcoma: Compared to the sham group, the SNL group had higher gene expression levels of Gadd45g (growth arrest and DNA-damage-inducible 45 gamma) and Fos (FBJ osteosarcoma oncogene), while it had lower gene expression levels of Igf1, Ccl2, Hdac2, Rtn4rl1, Nfkb2, Gpr84, Pik3cg, and Abcc8 (Figure 3A).