In our study, among the cases of confirmed sepsis (identified by the presence of bacteria in the bloodstream), P-SEP determined upon admission was always above 2000 pg/mL, and is higher when CRP is more than 75 mg/dL, making it a useful diagnostic finding, especially considering the single septic child who presented with elevated P-SEP but CRP and PCT values that were lower than what is considered significant. This evidence concerns the gene CALCA and Sepsis.