Chang et al.’s meta-analysis highlighted the effectiveness of soluble TREM-1 (sTREM-1) as a biomarker, with its impressive diagnostic and prognostic capabilities demonstrated by high sensitivity (0.95), specificity (0.98), and an area under the SROC curve of 0.99 for neonatal sepsis [30]. This evidence concerns the gene TREM1 and Neonatal sepsis.