In fact, normally, tolerance induction occurs through the conversion of naïve T cells into regulatory T cells (Treg), which are responsible for the inhibition of IgE development and thus FA through the action of CD103+ dendritic cells, triggered by the production of mucin by intestinal epithelial cells and granulocyte-macrophage colony-stimulating factor (GM-CSF) by innate lymphoid cell type 3 (ILC3). The gene discussed is CSF2; the disease is Friedreich ataxia.