Moreover, mRNA of L-type CaV1.2 channels are highly expressed in the cerebral cortex, the pituitary gland, the amygdala, the basal ganglia, and also in the cerebellum [8].In mouse models of ataxia and epilepsy, cerebellar calcium channels such as Cav1.2 were significantly reduced in number [33]. This evidence concerns the gene CACNA1C and Ataxia.