The inhibition of TNF-α through thalidomide (TLD) and its derivative 3,6’-dithiothalidomide (DTT) in the 6-OHDA rat model of PD attenuated LID scores via an anti-angiogenic activity in basal ganglia and an overexpression of GLUR1 [102,103,104,105,106,107,108,109]. The gene discussed is TNF; the disease is Parkinson disease.