Figure 2A shows representative EPSC traces before and after TBS stimulation in the four groups of mice used in this study. The ratio of LTP was significantly reduced in the STZ-induced animal model of AD compared to that in control mice. The depression of LTP 30 min after TBS in the STZ-induced animal model of AD treated with Apelin-13 confirmed that Apelin-13 significantly enhances the magnitude of LTP (Figure 2B,C, n = 8, one-way ANOVA, p < 0.05). This evidence concerns the gene APLN and Alzheimer disease.