RHOA and heart failure: In the paper showing that the NO/ONOO(-) cycle is central to the etiology of heart failure, it was shown that RhoA functioned as possibly tissue-limited cycle element [209]. RhoA is implicated as a causal element of autism/ASDs, including in stabilization of synapses (Richter et al. [239]; Luo et al. [240]. Hayashi et al. [241]), providing further evidence consistent with a NO/ONOO(-) cycle role in autism/ASDs.