AFP and germ cell tumor: The American Children’s Oncology Group CNS Nongerminomatous Germ Cell Tumor Phase II Trial (ACNS1123) [7] sets HCG at 100 IU/L and AFP at 10 ng/mL, while the European SIOP GCT II Trial [8] sets HCG at 50 IU/L and AFP at 25 ng/mL.